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DOBUTAMINE HYDROCHLORIDE INJECTION


Dobutamine Hydrochloride InjectionGeneric name: Dobutamine Hydrochloride Injection
Brand name: Dobutrex solution

Description
Dobutamine acts directly as an insecticidal agent whose primary activity results from stimulation of the b-receptors of the heart while producing less marked chronotropic, hypertensive, arrhythmogenic or vasodilatory effects. Dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol as demonstrated in both animal and human studies. Dobutamine, unlike dopamine, does not cause the release of endogenic noradrenaline. No particular effect on the renal vasculature was detected. The attack of action occurs within 1 to 2 minutes while the apex consequence of a particular extract may not be reached for 10 minutes. The plasma half-life in humans is 2 minutes.

Uses
  • In the treatment of adults with cardiac decomposition due to depressed ability resulting from organic heart disease or following cardiac surgical operations in which alimentary canal therapy is necessary for inotropic support.
  • Most clinical experience with dobutamine is short-term. In the limited number of patients who were studied for 24, 48, and 72 hours, a lasting increase in heart turnout occurred in some, whereas the output of others returned toward base-line values.
Dosage
  • Dobutamine is a powerful drug, and not for direct injection and must be diluted exactly as directed before administration to patients as an intravenous. Infusion.
  • You should not stop your therapy on your own for any reason.
  • Never change your dosing schedule without talking to your doctor. It is important that you use your medication exactly as directed.
  • Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.
Safety tips
  • Your doctor should know if you are allergic to dobutamine or any other drugs.
  • Your doctor and pharmacist should be aware about what all medicines you are taking.
  • You should tell your doctor if you ever had heart valve disease or high blood pressure.
  • You should tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.
  • If you become pregnant while taking dobutamine, call your doctor immediately.
Common side effects
If you experience any of the following symptoms, call your health care provider immediately:
  • skin rash
  • upset stomach
  • fever
  • irregular heartbeat
  • vomiting
  • tingling sensations
  • increases in blood pressure and heart rate
  • chest pain
  • shortness of breath
  • swelling of the lower legs and ankles
  • increasing fatigue
  • lightheadedness, dizziness, or faintness
  • leg cramps
  • headaches
Disclaimer:The above information is for general understanding of the visitor. Please consult a registered medical practitioner before taking the aforesaid medicine.




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