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ZOLEDRONIC ACID


Generic name: Zoledronic Acid
Brand name: Zometa

Description
Zoledronic acid is a white powder. Its molecular formula is C5H10N2O7P2 • H2O. Zoledronic acid is highly soluble in sodium hydroxide solution, sparingly soluble in water and hydrochloric acid, and practically insoluble in organic solvents. The pH of a 0.7% solution of Zoledronic acid in water is nearly 2.0

Uses
  • Zolendronic Acid is used in the treatment of bones (hypercalcemia of malignancy) caused by cancer.
  • It is used in the treatment of patients with multiple myeloma and patients with documented bone metastases from solid tumors, in conjunction with standard antineoplastic therapy.
  • It is also beneficial during ocular inflammation such as uveitis and scleritis.
  • Zoledronic acid minimizes the discharge and breakdown of calcium from bone. It is used when high amount of calcium is found in the blood of the patient to lower the blood calcium levels. High blood calcium levels can make the person confused and tired which results into continuous stomach pain and muscle weakness. Zoledronic acid helps to relieve these symptoms.
  • Zoledronic acid is also used to prevent chances of bone cancer.
Dosage
Zoledronic acid is for injection or infusion into a vein. It is given by a healthcare professional, usually in a hospital or clinic setting. The maximum recommended dose of zoledronic in hypercalcemia of malignancy is 4 mg. The 4-mg dose must be given as a single-dose intravenous infusion over no less than 15 minutes. Patients who receive it, should have serum creatinine assessed prior to each treatment. Dose adjustments are not necessary in treating patients for hypercalcemia of malignancy presenting with mild-to-moderate renal impairment prior to initiate the therapy.

Safety tips
  • Your doctor should know if you are suffering from aspirin sensitive asthma, kidney or dental disease.
  • Your doctor should also be informed if you have allergy from Zoledronic acid or any other medicines or chemical, or you are pregnant or doing breeast feeding.
  • Visit your health care professional for regular check ups.
  • You should talk with your doctor about your dietary or supplement needs.
  • You should not take supplements without your doctor's advice.
  • Your Doctor should be aware of your medical history.
Common side effects
Following are the few side effects which occurs due to improper dose and different radiations.
  • constant jaw pain, especially burning or cramping
  • eye inflammation, pain, or vision change
  • muscle cramps or weakness
  • pain or difficulty passing urine
  • very stiff muscles, unable to move easily
  • bone pain
  • nausea, vomiting
  • loss of appetite
Disclaimer:The above information is for general understanding of the visitor. Please consult a registered medical practitioner before taking the aforesaid medicine.




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